Coding

Part:BBa_K364201:Experience

Designed by: Lior Malka   Group: iGEM10_Debrecen-Hungary   (2010-08-05)

This experience page is provided so that any user may enter their experience using this part.
Please enter how you used this part and how it worked out.


Physiological functions of PXR

The primary function of PXR is to sense the presence of foreign toxic substances and in response up regulate the expression of proteins involved in the detoxification and clearance of these substances from the body.

One of the primary targets of PXR activation is the induction of CYP3A4, an important phase I oxidative enzyme that is responsible for the metabolism of many drugs. In addition, PXR up regulates the expression of phase II conjugating enzymes such as glutathione S-transferase and phase III transport uptake and efflux proteins such as OATP2 and MDR1.

Possible applications of PXR DBD

This part can be used for assembling various nuclear receptor composites by fusing with different LBDs (and also with hinge).

Applications of BBa_K364201